関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydroxide | HCID 961 | — |
| 反応物 | Methyl vinyl ketone | HCID 6570 | — |
| 反応物 | 2,3,6-Trimethylphenol | HCID 17016 | — |
| 反応物 | N,N,N-Trimethyl-3-oxobutan-1-aminium iodide | HCID 35720 | — |
| 反応物 | 4-Chloro-2-butanone | HCID 80608 | — |
| 反応物 | 4-Hydroxy-2-Butanone | HCID 111509 | — |
| 反応物 | 2-Butanone, 4-methoxy- | HCID 138889 | — |
| 反応物 | 4-(Acetyloxy)-2-butanone | HCID 139100 | — |
| 反応物 | Hydride | HCID 166653 | — |
| 反応物 | 4-(Dimethylamino)butan-2-one | HCID 546913 | — |
| 反応物 | 2-Butanone, 4-(benzoyloxy)- | HCID 10899468 | — |
| 反応物 | 4-Phenoxybutan-2-one | HCID 11744969 | — |
| 反応物 | Methyl beta-phenylsulfonyloxyethyl ketone | HCID 22757839 | — |
| 反応物 | Dimethyl-(beta-acetylethyl)-sulfonium bromide | HCID 22757840 | — |
| 溶媒 | Ethyl ketone | HCID 7288 | — |
| 生成物 | 2,3,6-Trimethylcyclohex-2-en-1-one | HCID 3016843 | — |
反応手順
A process for the production of 2,3,6-trimethylphenol which comprises reacting a carbonyl compound selected from the group consisting of methyl vinyl ketone, methyl β-hydroxyethyl ketone, methyl β-methoxyethyl ketone, methyl β-phenoxyethyl ketone, methyl β-acetyloxyethyl ketone, methyl β-benzoyloxyethyl ketone, methyl β-methyl-sulfonyloxyethyl ketone, methyl β-phenylsulfonyloxyethyl ketone, methyl β-dimethylaminoethyl ketone, methyl β-chloroethyl ketone, dimethyl-(β-acetylethyl)-sulfonium bromide or trimethyl-(β-acetylethyl)-ammonium iodide to a mixture of diethyl ketone and a basic reagent selected from the group consisting of an alkali metal, an alkaline earth metal, a hydroxide, oxide, alcoholate, amide, hydride or organo metallic compound of an alkali metal or alkaline earth metal, and a quaternary ammonium hydroxide, the amount of said diethyl ketone being in the molar ratio of 1:1 to 50:1 with respect to the total amount of carbonyl compound added, at a reaction temperature of 20° to 150° C. to produce 2,3,6-trimethyl-2-cyclohexen-1-one, and dehydrogenating the latter to produce 2,3,6-trimethylphenol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04128728 |
|---|
| 出典データセット | uspto-grants-1978_12 |
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| ORD ID | ord-9b33e77963df4df4b4320925a5d1e81f |
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| 出典メモ | uspto-grants-1978_12 |
|---|
