Acetone → HCID 178484388、化合物
反応式
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].CC(C)=O.O.[C:15]([OH:23])(=[O:22])[CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>CC(C)=O.O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:15]([O-:23])(=[O:22])[CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20]参加物
6
反応条件
- 温度
- 10 °C
実験手順
9.75 g (2.5 molar equivalents) of the metformin free-base was stirred in a mixed solution of 112.5 ml of acetone and 5 ml of water at 40° C., and a solution of 3.98 g (1 molar equivalent) of glutaric acid in acetone-water was added dropwise thereto and stirred at 10° C. The produced crystal was filtered and dried in hot air, thus obtaining 11.24 g (yield: 95.3%) of metformin glutarate.
後処理
- filtrationThe produced crystal was filtered
- customdried in hot air
出典と根拠
- ORDレコード
- ord-b1476a9df4084ce29a100deb4b1d44bd
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076377B2
反応ノート
読み込み中…