Glutaric Acid → HCID 178484388、化合物
反応式
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([OH:18])(=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15]>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([O-:18])(=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15]参加物
4
反応条件
- 温度
- 10 °C
実験手順
9.75 g (2.5 molar equivalents) of metformin free-base was stirred in 100 ml of ethanol at room temperature, after which a solution of 3.98 g (1 molar equivalent) of glutaric acid in ethanol was added dropwise thereto and stirred at 10° C. The produced crystal was filtered and dried in hot air, thus obtaining 7.41 g (yield: 62.8%) of metformin glutarate.
後処理
- filtrationThe produced crystal was filtered
- customdried in hot air
出典と根拠
- ORDレコード
- ord-09d290427ad24818acec574a57285988
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076377B2
反応ノート
読み込み中…