Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylate → Methyl thieno[2,3-b]pyridine-2-carboxylate

HRID 658152

反応式

HRID 658152 の反応式
N[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[C:11]([O:13][CH3:14])=[O:12].N([O-])=O.[Na+]>>[S:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[CH:2]=[C:3]1[C:11]([O:13][CH3:14])=[O:12]

参加物

3

反応物 2

HCID 2820896Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylateHCID 23668193Sodium Nitrite

生成物 1

HCID 19007380Methyl thieno[2,3-b]pyridine-2-carboxylate

実験手順

The synthesis is carried out according to the general procedure; for work-up, the resulting precipitate is filtered off with suction and washed twice with water and three times with ethyl acetate. The organic phase of the resulting filtrate is separated off, dried and concentrated. Using 0.22 g (1.07 mmol) of methyl 3-aminothieno[2,3-b]pyridine-2-carboxylate and 0.24 g (3.41 mmol) of sodium nitrite, 84 mg (41% of theory) of the desired product are obtained.

後処理

  1. filtrationfor work-up, the resulting precipitate is filtered off with suction
  2. washwashed twice with water and three times with ethyl acetate
  3. customThe organic phase of the resulting filtrate is separated off
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-28e46e2cb2014e02ab6e4d0a5b122ce3
出典データセット
uspto-grants-2011_12
特許番号
US08076355B2

関連ノート

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