N,O-Dimethylhydroxylamine → Urea, N-methoxy-N-methyl-N'-(4-(2-(4-methylphenyl)ethoxy)phenyl)-

HRID 65819

反応式

HRID 65819 の反応式
[CH3:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[CH3:20][NH:21][O:22][CH3:23]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:17])[N:21]([O:22][CH3:23])[CH3:20])=[CH:11][CH:10]=2)=[CH:18][CH:19]=1

参加物

4

反応物 2

HCID 14232N,O-DimethylhydroxylamineHCID 130176584-(4-Methylphenethyloxy)phenyl isocyanate

生成物 1

HCID 93385Urea, N-methoxy-N-methyl-N'-(4-(2-(4-methylphenyl)ethoxy)phenyl)-収率 108.4%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

Into a solution of 5.5 g of 4-(4-methylphenethyloxy)phenyl isocyanate in 100 ml of benzene, a solution of 2 g of N,O-dimethylhydroxylamine in 50 ml of benzene is added dropwise at 20° to 30° C. After the addition is finished, the reaction mixture is continuously stirred at the same temperature for an additional 30 minutes. Thereafter, the solvent is removed under reduced pressure, and the residue is recrystallized from ethanol to obtain 7.4 g of N'-[4-(4-methylphenethyloxy)phenyl]-N-methoxy-N-methylurea as white needles, M.P. 82°-83° C.

後処理

  1. additionAfter the addition
  2. customThereafter, the solvent is removed under reduced pressure
  3. customthe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-a066c1df694a417684942b3232fa807c
出典データセット
uspto-grants-1978_12
特許番号
US04129436

関連ノート

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