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Pyridine → N'-[4-(4-tert-butylphenethyloxy)phenyl]-N-methoxy-N-methylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Einecs 211-027-4 | HCID 69401 | — |
| 反応物 | N-methoxy-N-methylcarbamoyl chloride | HCID 2734926 | — |
| 反応物 | 4-(4-Tert-butylphenethyloxy)aniline | HCID 22756001 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N'-[4-(4-tert-butylphenethyloxy)phenyl]-N-methoxy-N-methylurea | HCID 22756005 | 26.1% |
反応手順
A mixture of 26.9 g of 4-(4-tert-butylphenethyloxy)aniline, 13 g of N-methoxy-N-methylcarbamyl chloride, 10 ml of pyridine and 300 ml of toluene is heated under reflux for 7 hours. Thereafter, water is added to dissolve pyridinium chloride, and the separated toluene layer is washed with dilute hydrochloric acid, thoroughly washed with water and dried over anhydrous sodium sulfate. The solvent is then removed under reduced pressure, and the crude crystals obtained are repeatedly recrystallized from ethanol to obtain 9.3 g of N'-[4-(4-tert-butylphenethyloxy)phenyl]-N-methoxy-N-methylurea as white needles, M.P. 14°-15° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04129436 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-af08b02af2aa4bca8204bcf5fa2b9ff0 |
| 出典メモ | uspto-grants-1978_12 |