1-(1H-imidazole-1-carboximidoyl)-1H-imidazole → [4-(5-Amino-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-(2-fluoro-4-iodo-phenyl)-amine

HRID 658363ノート

反応式

HRID 658363 の反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:19]=[N:18][CH:17]=[CH:16][C:11]=1[C:12]([NH:14][NH2:15])=[O:13].[N:20]1(C(=N)N2C=CN=C2)C=CN=[CH:21]1>CS(C)=O>[NH2:20][C:21]1[O:13][C:12]([C:11]2[CH:16]=[CH:17][N:18]=[CH:19][C:10]=2[NH:9][C:3]2[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=2[F:1])=[N:14][N:15]=1

参加物

4

反応物 2

HCID 113556541-(1H-imidazole-1-carboximidoyl)-1H-imidazoleHCID 115888023-[(2-Fluoro-4-iodophenyl)amino]isonicotinohydrazide

生成物 1

HCID 17747573[4-(5-Amino-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-(2-fluoro-4-iodo-phenyl)-amine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-isonicotinic acid hydrazide (1 g, 2.68 mmol) in DMSO (6 mL) were added 1,1-di-1H-imidazol-1-yl-methyleneamine (864 mg, 5.36 mmol). The reaction mixture was stirred at RT for 18 h. Quenching of the reaction by adding water (60 mL). A solid precipitated out. The solid was filtered, washed with water and cold methanol. Yield: white solid 1.0 g. LC-MS (Method A) [4.66 min; 398(M+1)].

後処理

  1. customQuenching of the reaction
  2. additionby adding water (60 mL)
  3. customA solid precipitated out
  4. filtrationThe solid was filtered
  5. washwashed with water and cold methanol
  6. customLC-MS (Method A) [4.66 min; 398(M+1)]

出典と根拠

ORDレコード
ord-7a28ea4cd7e24d478c5dcd4e04b62212
出典データセット
uspto-grants-2011_12
特許番号
US08076486B2

反応ノート

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