Methyl Isocyanate → 2-(3-(2-fluoro-4-iodophenylamino)isonicotinoyl)-N-methylhydrazinecarboxamide
反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:19]=[N:18][CH:17]=[CH:16][C:11]=1[C:12]([NH:14][NH2:15])=[O:13].[CH3:20][N:21]=[C:22]=[O:23]>CO>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:19]=[N:18][CH:17]=[CH:16][C:11]=1[C:12]([NH:14][NH:15][C:22]([NH:21][CH3:20])=[O:23])=[O:13]参加物
4
実験手順
To a suspension of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinohydrazide (200 mg; 0.54 mmol) in methanol (10 mL) was added (methylimino)(oxo)methane (61 mg; 1.07 mmol) (methyl Isocyanate). After few minutes the reaction mixture became homogeneous, and then an yellow colored solid, 2-{3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}-N-methylhydrazinecarboxamide (50 mg) was separated out. The filtrate upon concentration gave 158 mg which was also pure. (208 mg, 90%) MS m/z: 429 M+1