5-(4-Amino-3-fluorophenoxy)-N-methylnicotinamide → 5-(4-Aminophenoxy)-N-methylnicotinamide

HRID 658487ノート

反応式

HRID 658487 の反応式
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[N:9][CH:10]=[C:11]([CH:16]=2)[C:12]([NH:14][CH3:15])=[O:13])=[CH:4][C:3]=1F.COC(=O)C1C=C(OC2C=CC(N)=C(F)C=2)C=NC=1>>[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[N:9][CH:10]=[C:11]([CH:16]=2)[C:12]([NH:14][CH3:15])=[O:13])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 583854225-(4-Amino-3-fluorophenoxy)-N-methylnicotinamideHCID 599875035-(4-Amino-3-fluorophenoxy)nicotinic acid methyl ester

生成物 1

HCID 583853825-(4-Aminophenoxy)-N-methylnicotinamide

実験手順

The title compound was prepared in the same manner described for 5-(4-amino-3-fluorophenoxy)-N-methylnicotinamide, substituting 5-(4-aminophenoxy)nicotinic acid methyl ester for 5-(4-amino-3-fluorophenoxy)nicotinic acid methyl ester. 1H NMR (DMSO-d6) δ 8.65 (m, 2H), 8.40 (d, J=2.7 Hz, 1H), 7.52 (t, J=2.2 Hz, 1H), 6.84 (d, J=8.7 Hz, 2H), 6.62 (d, J=8.7 Hz, 2H), 5.01 (s, 2H), 2.75 (d, J=4.4 Hz, 3H); MS LC-MS [M+H]+=244.2, RT=0.29 min.

出典と根拠

ORDレコード
ord-6a9bc59412df4210bef5b7dff7a87aea
出典データセット
uspto-grants-2011_12
特許番号
US08076488B2

反応ノート

読み込み中…