Benzyl Bromide → Ethyl 4-(phenylmethoxy)benzoate

HRID 6585

反応式

HRID 6585 の反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(CC1C=CC=CC=1)(C1C=CC=CC=1)=O.[OH:24][C:25]1[CH:35]=[CH:34][C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:27][CH:26]=1.C([O-])([O-])=O.[Cs+].[Cs+]>O.CN(C=O)C>[CH2:1]([O:24][C:25]1[CH:26]=[CH:27][C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:34][CH:35]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 7498Benzyl BromideHCID 8434EthylparabenHCID 99482-PhenylacetophenoneHCID 10796Cesium carbonate

生成物 1

HCID 191414Ethyl 4-(phenylmethoxy)benzoate収率 100%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

35 mmol of benzyl bromide (BzBn, 35 mmol of ethyl 4-hydroxybenzoate (10), 14 g of Cs2CO3 and 40 ml of DMF were combined and stirred at RT ove night. Then the reaction mixture was poured into water and the product was collected by extraction. The organic solution was washed with brine and dried over MgSO4. After evaporation of solvent, pure product was obtained in yield of 100%.

後処理

  1. customthe product was collected by extraction
  2. washThe organic solution was washed with brine
  3. dry with materialdried over MgSO4
  4. customAfter evaporation of solvent
  5. custompure product was obtained in yield of 100%

出典と根拠

ORDレコード
ord-424348839da04f94a84ae091f5ab15fa
出典データセット
uspto-grants-2006_08
特許番号
US07083832B2

関連ノート

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