Sodium Chloride → N-acetyl-DL-cysteinyl-L-proline
反応式
[C:1]([NH:4][CH:5]([C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])=[O:12])[CH2:6][S:7]C(=O)C)(=[O:3])[CH3:2].[Cl-].[Na+]>O.N>[C:1]([NH:4][CH:5]([C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([OH:17])=[O:16])=[O:12])[CH2:6][SH:7])(=[O:3])[CH3:2]参加物
5
実験手順
N,S-Diacetyl-DL-cysteinyl-L-proline (0.3 g) is dissolved in a mixture of water (4 ml) and concentrated ammonia (4 ml) under a blanket of argon. The solution is stored for 30 minutes at room temperature, saturated with sodium chloride and extracted with ethyl acetate and chloroform. The organic layers are pooled and concentrated to dryness in vacuo to obtain N-acetyl-DL-cysteinyl-L-proline, yield 0.1 g, Rf =0.25 (silica gel; benzene:acetic acid, 75:25).
後処理
- extractionextracted with ethyl acetate and chloroform
- concentrationconcentrated to dryness in vacuo
出典と根拠
- ORDレコード
- ord-ad3e708911514574abd75de3d8c441a0
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04129571
反応ノート
読み込み中…