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HRID 658781作成日：2026年10月26日

4-(Chloromethyl)-1-fluoro-2-methoxybenzene → 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(4-fluoro-3-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

https://huagongshe.com/reaction/658781

反応式

関与物質

役割名称HCID仕込み量
反応物4-(Chloromethyl)-1-fluoro-2-methoxybenzeneHCID 17964239—
反応物3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dioneHCID 59524388—
生成物3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(4-fluoro-3-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dioneHCID 53375152—

反応手順

Prepared as in Example 12-16 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione (Example 12-16a) and 4-(chloromethyl)-1-fluoro-2-methoxybenzene. MS 442 (MH+). The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.18 μM.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08076491B2
出典データセットuspto-grants-2011_12
ORD IDord-dbfd66781db54d8e97802f77c6c01b4f
出典メモuspto-grants-2011_12