tert-Butyldimethylsilyl chloride → HCID 59524419、化合物

反応式

Cl.[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C@H:8]([C:13]([O:15][CH3:16])=[O:14])[NH:9][CH2:10]2)=[CH:5][CH:4]=1.[C:17]([Si:21](Cl)([CH3:23])[CH3:22])([CH3:20])([CH3:19])[CH3:18]>>[Si:21]([O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C@H:8]([C:13]([O:15][CH3:16])=[O:14])[NH:9][CH2:10]2)=[CH:5][CH:4]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:23])[CH3:22]

参加物

反応物 2

HCID 28928tert-Butyldimethylsilyl chloride

HCID 66975332Methyl (R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride

生成物 1

HCID 59524419HCID 59524419、化合物収率 79%

実験手順

Prepared as in Example 1c-JF from (R)-methyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (Example 13-2c) and tert-butylchlorodimethylsilane. Yield 79%, yellow oil (1.15 g, 79%). MS 322 (MH+).

出典と根拠

ORDレコード: ord-0eee3b53d82e45d5b9d0d8b39cfc68d6
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08076491B2

反応ノート

読み込み中…