Cyclopentylacetylene → Tert-butyl 3-(3-(cyclopentylethynyl)phenyl)-3-hydroxypropylcarbamate

反応式

[C:1]([CH:3]1[CH2:7][CH2:6][CH2:5][CH2:4]1)#[CH:2].Br[C:9]1[CH:10]=[C:11]([CH:15]([OH:26])[CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH:12]=[CH:13][CH:14]=1>>[CH:3]1([C:1]#[C:2][C:9]2[CH:10]=[C:11]([CH:15]([OH:26])[CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:24])[CH3:23])[CH:12]=[CH:13][CH:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4]1

参加物

反応物 2

HCID 136725Cyclopentylacetylene

HCID 57608439Tert-butyl 3-(3-bromophenyl)-3-hydroxypropylcarbamate

生成物 1

HCID 57608534Tert-butyl 3-(3-(cyclopentylethynyl)phenyl)-3-hydroxypropylcarbamate

実験手順

Coupling of ethynylcyclopentane (40) with tert-butyl 3-(3-bromophenyl)-3-hydroxypropylcarbamate (39) following the method used in the synthesis of Example 13 gave tert-butyl 3-(3-(cyclopentylethynyl)phenyl)-3-hydroxypropylcarbamate (41) as a brown oil. Yield (0.386 g, 92%).

後処理

customused in the synthesis of Example 13

出典と根拠

ORDレコード: ord-75c8daafdd31457ba7f43857c88ef301
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08076516B2

反応ノート

読み込み中…