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Dimethylformamide → 2,2,2-trifluoro-N-(3-(3-(3-hydroxy-3,4,4-trimethylpent-1-ynyl)phenyl)propyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3,4,4-Trimethyl-1-pentyn-3-ol | HCID 136777 | — |
| 反応物 | N-(3-(3-bromophenyl)propyl)-2,2,2-trifluoroacetamide | HCID 57608389 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 2,2,2-trifluoro-N-(3-(3-(3-hydroxy-3,4,4-trimethylpent-1-ynyl)phenyl)propyl)acetamide | HCID 86628451 | — |
反応手順
Coupling of 3,4,4-trimethylpent-1-yn-3-ol with bromide 10 in a 1:1 mixture of DMF and triethylamine gave 2,2,2-trifluoro-N-(3-(3-(3-hydroxy-3,4,4-trimethylpent-1-ynyl)phenyl)propyl)acetamide as an orange oil. Yield (0.84 g, 73%): 1H NMR (400 MHz, CD3OD) δ 7.15-7.25 (, 4H), 3.29 (t, J=7.2 Hz, 2H), 2.61 (t, J=8.0 Hz, 2H), 1.86 (quint, J=7.6 Hz, 2H), 1.49 (s, 3H), 1.09 (br s, 9H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08076516B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-08d6175ba5ef4a8da1886af63e378c01 |
| 出典メモ | uspto-grants-2011_12 |