Methanol → HCID 23249620、化合物

HRID 658961ノート

反応式

HRID 658961 の反応式
[O:1]([CH2:9][CH2:10][CH2:11][CH2:12]/[CH:13]=[C:14](\[CH3:20])/[C:15](OCC)=[O:16])[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].[H-].C([Al+]CC(C)C)C(C)C.CCCCCC.CO.O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C(Cl)Cl>[O:1]([CH2:9][CH2:10][CH2:11][CH2:12]/[CH:13]=[C:14](\[CH3:20])/[CH2:15][OH:16])[Si:2]([C:5]([CH3:7])([CH3:8])[CH3:6])([CH3:4])[CH3:3]

参加物

6

反応物 4

HCID 887MethanolHCID 62649Sodium sulfate decahydrateHCID 11055704(E)-ethyl 7-(tert-butyldimethylsiloxy)-2-methyl-2-heptenateHCID 21273587HCID 21273587、化合物

生成物 1

HCID 23249620HCID 23249620、化合物収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a methylene chloride solution (200 ml) of Ester 4 (15.84 g; 0.0528 mol), a 0.95 M diisobutylaluminiumhydride-hexane solution (139 ml; 0.132 mol) is added at 0° C. and the whole is stirred for 1 hour. After stirring, methanol (7 ml; 0.160 mol) and sodium sulfate decahydrate (68.0 g; 0.211 mol) are added thereto and the whole is stirred at room temperature for 30 min. Sodiumsulfatedecahydrate is filtered using Chloroform (21), and the solvent is distilled off under reduced pressure to produce Alcohol 5 (13.60 g; 0.0528 mol) of 100% in yield.

後処理

  1. stirringAfter stirring
  2. stirringthe whole is stirred at room temperature for 30 min
  3. filtrationSodiumsulfatedecahydrate is filtered
  4. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-40b47e8a91e14055884f7acca915c8ef
出典データセット
uspto-grants-2011_12
特許番号
USRE043038E1

反応ノート

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