化工社化工社 化学情報印刷レポート · 研究参考用
Diisopropylethylamine → 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| 反応物 | 5-Phenoxyfuran-2-carboxylic acid | HCID 2812790 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid | HCID 68413660 | — |
反応手順
5-phenoxy-2-furoic acid (3) (213 mg, 1.05 mmol) was coupled to aniline (2) (200 mg, 1.05 mmol) using Method B, except that DIPEA (270 mg, 2.09 mmol) and DMF (2 mL) were used to give the title compound. Yield: 178 mg, 96%; LC/MS tr 1.65 min; HPLC Purity: 95%; MS (ES+) m/z 378 (M+H)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08080567B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-b572637309d44c8aa5c4bf03177b49eb |
| 出典メモ | uspto-grants-2011_12 |