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Diisopropylethylamine → 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| 反応物 | 5-Benzoylfuran-2-carboxylic acid | HCID 2877255 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68412610 | — |
反応手順
Acid (9) (48 mg, 0.22 mmol) was coupled to aniline (2) (43 mg, 0.22 mmol) using Method B, except that DIPEA (57 mg, 0.44 mmol) and DMF (0.5 mL) were used. The crude product was purified by preparative HPLC to give the title compound. Yield: 28 mg; LC-MS tr 41.54 min; MS (ES+) m/z 389 (M+H)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08080567B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-1a215cd9103e447a89e05584481b6c9e |
| 出典メモ | uspto-grants-2011_12 |