関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | m-Bromobenzenethiol | HCID 80597 | — |
| 反応物 | 2-Bromo-6-phenylpyridine | HCID 568679 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-(3-Bromo-phenylsulfanyl)-6-phenyl-pyridine | HCID 59334847 | — |
反応手順
2-Bromo-6-phenyl-pyridine (13) (100 mg, 0.43 mmol), K2CO3 (117 mg, 0.85 mmol) in acetone (2 mL) was added 3-bromothiophenol and the reaction mixture was heated in a CEM Discover microwave for 1×30 minutes at 90° C., then 4×2 hours at 130° C., followed by 1×8 hours at 130° C. The crude product was partially purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound. Yield: 100 mg, 68%; LC-MS tr 1.97 min; HPLC Purity: 55%; MS (ES+) m/z 342, 344 (M+H)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08080567B2 |
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| 出典データセット | uspto-grants-2011_12 |
|---|
| ORD ID | ord-58e384b3446a4a7aaa4b35a0f80dddbb |
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| 出典メモ | uspto-grants-2011_12 |
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