関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Bromobenzene | HCID 7961 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Furan-2-boronic acid | HCID 2734357 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Phenylfuran | HCID 519363 | — |
反応手順
Furan-2-boronic acid (22) (3.6 g, 32.14 mmol) was coupled to bromobenzene (21) (4.2 g, 26.79 mmol) using Method E, except that Cs2CO3 (17.47 g, 53.58 mmol), Pd(PPha)4 (6.20 g, 0.54 mmol), toluene (25 mL) and EtOH (25 mL) were used and the reaction heated in a CEM Discover microwave at 140° C. (200 W, 200 psi). The crude product was purified by dry-flash chromatography eluting with EtOAc in heptane to yield the title compound. Yield: 2.94 g, 62%; LC tr 1.50 min; HPLC Purity: 84%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08080567B2 |
|---|
| 出典データセット | uspto-grants-2011_12 |
|---|
| ORD ID | ord-c5527ea8e52d4a509b9aae5f8e6b5360 |
|---|
| 出典メモ | uspto-grants-2011_12 |
|---|
