Methanol → 3-{4-Fluoro-3-[(5-phenyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid

関与物質

反応手順

The ester (44) (18 mg, 0.049 mmol) was hydrolysed using Method C, except that MeOH (1 mL), THF (1 mL) and 1M NaOH (2 mL) were used, and the reaction was stirred for 1 hour. Yield: 3 mg, 17%; LC-MS tr 1.44 min; HPLC Purity: 91%; MS (ES+) m/z 352 (M+H); 1H NMR (400 MHz; MeOH): δ 6.50 (d, 1H), 7.05 (d, 1H), 7.25-7.60 (m, 6H), 7.70 (d, 1H), 7.95 (d, 2H), 8.15 (d, 1H)

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