Hydrochloric Acid → cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride

HRID 659183

反応式

HRID 659183 の反応式
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([C@H:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@H:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66680888cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester

生成物 1

HCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride収率 85%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester (1.8 g, 6.7 mmol) was dissolved in dioxane. 4H HCl in dioxane (17 mL, 67 mmol) were added and the reaction mixture was stirred at room temperature overnight. The solvent was evaporated off. The residue was crystallized with ethanol and yielded cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride as a white solid (1.37 g, 85%), MS: m/e=169.2 [(M+H)+].

後処理

  1. customThe solvent was evaporated off
  2. customThe residue was crystallized with ethanol

出典と根拠

ORDレコード
ord-9401b56faf364cf2a2ea9ceacfb9a450
出典データセット
uspto-grants-2011_12
特許番号
US08080541B2

関連ノート

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