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HRID 659235作成日：2026年10月26日

1,4-Dibromo-2-butanol → N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-4,6-bis-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659235

反応式

関与物質

役割名称HCID仕込み量
反応物1,4-Dibromo-2-butanolHCID 29570—
反応物cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamideHCID 58062915—
生成物N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-4,6-bis-trifluoromethyl-benzamideHCID 76682981—

反応手順

The title compounds, both light yellow solids, MS: m/e=455.3 [(M+H)+], were prepared in accordance with the general method of example 10 from cis-N-(2-amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide (intermediate H) and 1,4-dibromo-2-butanol. The 2 diastereomers could be separated by column chromatography however the relative configuration was not assigned.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080541B2
出典データセットuspto-grants-2011_12
ORD IDord-14d90036ec694c1f9b1c206b9f242724
出典メモuspto-grants-2011_12