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HRID 659238作成日：2026年10月26日

2-Ethyl-4-(trifluoromethyl)benzoic acid → cis-2-Ethyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659238

反応式

関与物質

役割名称HCID仕込み量
反応物2-Ethyl-4-(trifluoromethyl)benzoic acidHCID 53406012—
反応物cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochlorideHCID 66680564—
生成物cis-2-Ethyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamideHCID 51001073—

反応手順

The title compound, white solid, MS: m/e=369.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-ethyl-4-(trifluoromethyl)-benzoic acid (CAS 854531-63-8).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080541B2
出典データセットuspto-grants-2011_12
ORD IDord-5c7ccd3e3054465bb1a7609cd2c1abdb
出典メモuspto-grants-2011_12