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HRID 659241作成日：2026年10月26日

1,4-Dibromo-2-butanol → cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659241

反応式

関与物質

役割名称HCID仕込み量
反応物1,4-Dibromo-2-butanolHCID 29570—
反応物cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamideHCID 58062914—
生成物cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamideHCID 58062933—

反応手順

The title compound, light yellow foam, MS: m/e=433.2 [(M+H)+], was prepared in accordance with the general method of example 10 from cis-N-(2-amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate I) and 1,4-dibromo-2-butanol. The two diastereomers were not separated.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080541B2
出典データセットuspto-grants-2011_12
ORD IDord-33ccdd02a4614fbbacbe2ffa7cae0f59
出典メモuspto-grants-2011_12