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2,4-Bis(trifluoromethyl)benzoic acid → N-((1RS,2SR)-2-Pyrrolidin-1-yl-cyclohexyl)-2,4-bis-trifluoromethyl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Bis(trifluoromethyl)benzoic acid | HCID 141752 | — |
| 反応物 | cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride | HCID 66680564 | — |
| 生成物 | N-((1RS,2SR)-2-Pyrrolidin-1-yl-cyclohexyl)-2,4-bis-trifluoromethyl-benzamide | HCID 76682967 | — |
反応手順
The title compound, white solid, MS: m/e=409.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2,4-bis(trifluoromethyl)benzoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08080541B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-0ca50ce8347b43a1b4349491bec9f3be |
| 出典メモ | uspto-grants-2011_12 |