2,4-Bis(trifluoromethyl)benzoic acid → N-((1RS,2SR)-2-Pyrrolidin-1-yl-cyclohexyl)-2,4-bis-trifluoromethyl-benzamide

HRID 659249

反応式

HRID 659249 の反応式
Cl.Cl.[N:3]1([C@H:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:14])[CH2:7][CH2:6][CH2:5][CH2:4]1.[F:15][C:16]([F:31])([F:30])[C:17]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:18]=1[C:19](O)=[O:20]>>[N:3]1([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]2[NH:14][C:19](=[O:20])[C:18]2[CH:22]=[CH:23][C:24]([C:26]([F:27])([F:28])[F:29])=[CH:25][C:17]=2[C:16]([F:15])([F:30])[F:31])[CH2:4][CH2:5][CH2:6][CH2:7]1

参加物

3

反応物 2

HCID 1417522,4-Bis(trifluoromethyl)benzoic acidHCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride2 回

生成物 1

HCID 76682967N-((1RS,2SR)-2-Pyrrolidin-1-yl-cyclohexyl)-2,4-bis-trifluoromethyl-benzamide

実験手順

The title compound, white solid, MS: m/e=409.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2,4-bis(trifluoromethyl)benzoic acid.

出典と根拠

ORDレコード
ord-0ca50ce8347b43a1b4349491bec9f3be
出典データセット
uspto-grants-2011_12
特許番号
US08080541B2

関連ノート

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