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HRID 659254作成日：2026年10月27日

2-Cyclopropyl-4-(trifluoromethyl)benzoic acid → cis-2-Cyclopropyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659254

反応式

関与物質

役割名称HCID仕込み量
反応物2-Cyclopropyl-4-(trifluoromethyl)benzoic acidHCID 59438485—
反応物cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochlorideHCID 66680564—
生成物cis-2-Cyclopropyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamideHCID 51000992—

反応手順

The title compound, white solid, MS: m/e=381.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-cyclopropyl-4-trifluoromethyl-benzoic acid (intermediate K).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080541B2
出典データセットuspto-grants-2011_12
ORD IDord-538ca34b2e1b4b4ba88da42ab81e391a
出典メモuspto-grants-2011_12