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HRID 659267作成日：2026年10月26日

2,4-Bis(trifluoromethyl)benzamide → 2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659267

反応式

関与物質

役割名称HCID仕込み量
反応物2,4-Bis(trifluoromethyl)benzamideHCID 2736099—
反応物1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodideHCID 11097568—
反応物N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamideHCID 66681196—
生成物2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamideHCID 66681255—

反応手順

The title compound, yellow gum, MS: m/e=431.3 [(M+H)+], was prepared in accordance with the general method of intermediate J from N-((1RS,2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and 1-ethyl-1-methyl-4-oxo-piperidinium iodide.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080541B2
出典データセットuspto-grants-2011_12
ORD IDord-8acf14e1272d42778769c8feec2f3a64
出典メモuspto-grants-2011_12