cis-2-Pyrrolidin-1-yl-cyclopentylamine → HCID 51001155、化合物

反応式

[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][C:13]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[C:14]=1[C:15](O)=[O:16]>>[CH3:12][C:13]1[CH:21]=[C:20]([C:22]([F:24])([F:25])[F:23])[CH:19]=[C:18]([C:26]([F:27])([F:28])[F:29])[C:14]=1[C:15]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:16]

参加物

反応物 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2 回

HCID 593477712-Methyl-4,6-bis(trifluoromethyl)benzoic acid

生成物 1

HCID 51001155HCID 51001155、化合物

実験手順

The title compound, white solid, MS: m/e=409.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-methyl-4,6-bis-trifluoromethyl-benzoic acid (CAS 895580-37-7).

出典と根拠

ORDレコード: ord-2881944572d744959b1b8d2ab45559c0
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08080541B2

反応ノート

読み込み中…