cis-2-Pyrrolidin-1-yl-cyclopentylamine → HCID 51000593、化合物

反応式

[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][S:13][C:14]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([C:27]([F:30])([F:29])[F:28])[C:15]=1[C:16](O)=[O:17]>>[CH3:12][S:13][C:14]1[CH:22]=[C:21]([C:23]([F:24])([F:26])[F:25])[CH:20]=[C:19]([C:27]([F:28])([F:29])[F:30])[C:15]=1[C:16]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:17]

参加物

反応物 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2 回

HCID 593478222-Methylthio-4,6-bis(trifluoromethyl)benzoic acid

生成物 1

HCID 51000593HCID 51000593、化合物

実験手順

The title compound, white solid, MS: m/e=441.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-methylsulfanyl-4,6-bis-trifluoromethyl-benzoic acid (CAS 896120-49-3).

出典と根拠

ORDレコード: ord-ff6955097f47451abcf262d1947eed08
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08080541B2

反応ノート

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