cis-2-Pyrrolidin-1-yl-cyclopentylamine → 2-Cyclopropyl-6-methoxy-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4 trifluoromethyl-benzamide

HRID 659298ノート

反応式

HRID 659298 の反応式
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:12]1([C:15]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([O:28][CH3:29])[C:16]=2[C:17](O)=[O:18])[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:23]=[C:22]([C:24]([F:26])([F:27])[F:25])[CH:21]=[C:20]([O:28][CH3:29])[C:16]=2[C:17]([NH:11][C@@H:7]2[CH2:8][CH2:9][CH2:10][C@@H:6]2[N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:18])[CH2:14][CH2:13]1

参加物

3

反応物 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2 回HCID 581677602-Cyclopropyl-6-methoxy-4-trifluoromethyl-benzoic acid

生成物 1

HCID 510012342-Cyclopropyl-6-methoxy-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4 trifluoromethyl-benzamide

実験手順

The title compound, light yellow solid, MS: m/e=397.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-cyclopropyl-6-methoxy-4-trifluoromethyl-benzoic acid (intermediate AS).

出典と根拠

ORDレコード
ord-bfedd314584e4232b864afb1d8ed3ba2
出典データセット
uspto-grants-2011_12
特許番号
US08080541B2

反応ノート

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