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Triethylamine → Cyclophosphamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phosphoramidic dichloride, bis(2-chloroethyl)- | HCID 96271 | — |
| 反応物 | Methylamino-1-phenyl-1-propanol | HCID 19933884 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Cyclophosphamide | HCID 2907 | — |
反応手順
A solution of bis(2-chloroethyl)phosphoramidic dichloride (10 mmol) in ethyl acetate (100 mL) is added dropwise to a solution of commercial 3 methylamino-1-phenyl-1-propanol (10 mmol) and triethylamine (20 mmol) in ethyl acetate (100 mL) at rt. After stirring at rt for 3 days, the salts are filtered off and the combined filtrates are concentrated under vacuum. The crude product is purified by column chromatography on silica.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08080536B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-ba24910390c54d239897abdfb963ae7b |
| 出典メモ | uspto-grants-2011_12 |