Dichloromethane → 2-(1-Bromoethyl)-3-chloro-1,4-difluorobenzene

HRID 659314ノート

反応式

HRID 659314 の反応式
P(Br)(Br)[Br:2].C(Cl)Cl.[Cl:8][C:9]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]([F:16])[C:10]=1[CH:17](O)[CH3:18]>O>[Br:2][CH:17]([C:10]1[C:9]([Cl:8])=[C:14]([F:15])[CH:13]=[CH:12][C:11]=1[F:16])[CH3:18]

参加物

5

反応物 3

HCID 6344Dichloromethane2 回HCID 24614Phosphorus tribromideHCID 211113742-Chloro-3,6-difluoro-α-methylbenzenemethanol

生成物 1

HCID 578860042-(1-Bromoethyl)-3-chloro-1,4-difluorobenzene収率 78%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Phosphorus tribromide (1.3 mL) and anhydrous CH2Cl2 (50 mL) were combined and then cooled over ice water for 20 minutes. The cooled solution was then added to a mixture of 1-(2-chloro-3,6-difluorophenyl)ethanol (2.71 g) and methylene chloride (50 mL), and the resulting mixture was stirred at room temperature for two (2) hours. The mixture was then poured into H2O and extracted into CH2Cl2. The organic phase was isolated, dried with magnesium sulfate, filtered, and concentrated to give the title compound (78% yield).

後処理

  1. extractionextracted into CH2Cl2
  2. customThe organic phase was isolated
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-927ec4335dd24913b359c537d8314ebb
出典データセット
uspto-grants-2011_12
特許番号
US08080561B2

反応ノート

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