Diisobutylaluminum hydride → 7-Iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
反応式
[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][C:8](=O)[NH:9][C:4]=2[CH:3]=1.CC(C[AlH]CC(C)C)C>>[I:1][C:2]1[CH:12]=[N:11][C:5]2[NH:6][CH2:7][CH2:8][NH:9][C:4]=2[CH:3]=1参加物
3
実験手順
7-Iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (200 mg) was reduced as in General Procedure 3 using 4 eq DIBAL-H to give the title compound as a white solid (31% yield). M.p. 126-128° C., LCMS: m/z=262.30 (M+H+), 1H-NMR (DMSO-d6, 400 MHz) δ 3.13-3.17 (m, 2H), 3.27-3.29 (m, 2H), 5.78 (s, 1H), 6.37 (s, 1H), 6.78 (d, J=2.0 Hz, 1H), 7.33 (d, J=2.0 Hz, 1H).
出典と根拠
- ORDレコード
- ord-7aaabe995c5e4ebea9b211a6bdc2e6a2
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08080561B2
反応ノート
読み込み中…