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HRID 659547作成日：2026年10月26日

1-((4-Methoxyphenyl)methyl)piperazine → (4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-[4-(4-methoxybenzyl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/659547

反応式

関与物質

役割名称HCID仕込み量
反応物1-((4-Methoxyphenyl)methyl)piperazineHCID 231905—
反応物4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acidHCID 46906718—
生成物(4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-[4-(4-methoxybenzyl)piperazin-1-yl]methanoneHCID 58327787—

反応手順

4-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 1-(4-methoxybenzyl)piperazine as in General Procedure 10 to give the title compound. LCMS: m/z=636.02 (M+H+); retention time=0.61 minutes.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08080561B2
出典データセットuspto-grants-2011_12
ORD IDord-3aaf04e7e4dd478b897c6e0eeccfde51
出典メモuspto-grants-2011_12