反応式
[N:1]1([CH:6]2[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[CH:5]=[CH:4][N:3]=[N:2]1.[ClH:19]>CO>[ClH:19].[N:1]1([CH:6]2[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]2)[CH:5]=[CH:4][N:3]=[N:2]1参加物
4
反応条件
- 温度
- 30 °C
実験手順
A 100-mL round-bottomed flask was charged with a solution of tert-butyl 3-(1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (2.8 g, 11.11 mmol, 1.00 equiv) in MeOH (50 mL). To this mixture was added conc. HCl (10 mL). The resulting solution was stirred at 30° C. for 5 hours in an oil bath. Upon completion, the resulting mixture was cooled down to room temperature and concentrated on a rotary evaporator affording 3-(1H-1,2,3-triazol-1-yl)piperidine hydrochloride as pale yellow solid (3 g).
後処理
- temperatureUpon completion, the resulting mixture was cooled down to room temperature
- concentrationconcentrated on a rotary evaporator
出典と根拠
- ORDレコード
- ord-bc852a0ebd4e4489a5648007dbcfc97b
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08080566B1
関連ノート
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