Ethyl trifluoroacetate → 1-Trifluoroacetyl-4-hydroxy-4-phenylpiperidine

HRID 65969ノート

反応式

HRID 65969 の反応式
[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[F:14][C:15]([F:22])([F:21])[C:16](OCC)=[O:17]>>[F:14][C:15]([F:22])([F:21])[C:16]([N:5]1[CH2:6][CH2:7][C:2]([OH:1])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:4]1)=[O:17]

参加物

3

反応物 2

HCID 9794Ethyl trifluoroacetateHCID 963874-Phenylpiperidin-4-ol

生成物 1

HCID 14465131-Trifluoroacetyl-4-hydroxy-4-phenylpiperidine

実験手順

The starting material is prepared as follows: The mixture of 25 g of 4-hydroxy-4-phenylpiperidine and 50 ml of ethyl trifluoroacetate is refluxed overnight and evaporated. The residue is taken up in benzene, the solution washed with 1N hydrochloric acid, dried and evaporated. The residue is recrystallized from ethyl acetate-petroleum ether, to yield the 1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine melting at 123°-125°.

後処理

  1. customThe starting material is prepared
  2. temperatureis refluxed overnight
  3. customevaporated
  4. washthe solution washed with 1N hydrochloric acid
  5. customdried
  6. customevaporated
  7. customThe residue is recrystallized from ethyl acetate-petroleum ether

出典と根拠

ORDレコード
ord-85b342c49efc47bd97c2025dfa1e28f5
出典データセット
uspto-grants-1978_12
特許番号
US04129655

反応ノート

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