2-Acetylamino-4-aminotoluene → 4-[2-(6-Chloro-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile

HRID 659742ノート

反応式

HRID 659742 の反応式
N[C:2]1[CH:3]=[CH:4][C:5]([CH3:22])=[C:6]([NH:8][C:9]2[O:10][C:11]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:12][N:13]=2)[CH:7]=1.[Cl:23]C1C(NC(=O)C)=C(C)C=CC=1.NC1C=CC(C)=C(NC(=O)C)C=1>>[Cl:23][C:7]1[C:6]([NH:8][C:9]2[O:10][C:11]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:12][N:13]=2)=[C:5]([CH3:22])[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 3

HCID 794922-Acetylamino-4-aminotolueneHCID 4226596N-(2-chloro-6-methylphenyl)acetamideHCID 177573464-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile

生成物 1

HCID 248719954-[2-(6-Chloro-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile収率 89%

実験手順

The same procedure outlined above in the preparation 4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile was used. However N-(6-chloro-2-methyl-phenyl)-acetamide was used instead N-(5-amino-2-methyl-phenyl)-acetamide. Yield=89%.

出典と根拠

ORDレコード
ord-2fb22d2cbb014747889d2b64502c490a
出典データセット
uspto-grants-2011_12
特許番号
US08080669B2

反応ノート

読み込み中…