Diethyl Oxalate → HCID 178488026、化合物

HRID 659824

反応式

HRID 659824 の反応式
Cl.Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([NH2:12])[C:8]([NH2:11])=[CH:9][CH:10]=1.[C:13](OCC)(=[O:19])[C:14](OCC)=[O:15].CCN(CC)CC>>[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:8](=[CH:9][CH:10]=1)[N:11]=[C:14]([OH:15])[C:13]([OH:19])=[N:12]2

参加物

4

反応物 3

HCID 7268Diethyl OxalateHCID 8471TriethylamineHCID 30851614-Methoxybenzene-1,2-diamine dihydrochloride

生成物 1

HCID 178488026HCID 178488026、化合物収率 69%

反応条件

温度
150 °C

実験手順

A suspension of 4-methoxybenzene-1,2-diamine dihydrochloride in diethyl oxalate (8 eq) was treated with Et3N (2 eq) and then heated at 150° C. for 2 h. The mixture was cooled and filtered, and then the collected solid was washed with H2O and EtOH. The residue was dried to give the title compound (69%). MS (ES+) m/z 193 (M+H)+

後処理

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. washthe collected solid was washed with H2O and EtOH
  4. customThe residue was dried

出典と根拠

ORDレコード
ord-806de296dabe4156bb1bcd9b679fb358
出典データセット
uspto-grants-2011_12
特許番号
US08080654B2

関連ノート

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