Anisole → (5-Bromo-2-fluoro-phenyl)-(4-methoxy-phenyl)-methanone

HRID 659879ノート

反応式

HRID 659879 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].[C:12]1([O:18][CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Cl-].[Cl-].[Cl-].[Al+3]>ClCCl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:7]([C:15]2[CH:16]=[CH:17][C:12]([O:18][CH3:19])=[CH:13][CH:14]=2)=[O:8])[CH:10]=1

参加物

5

反応物 3

HCID 7519AnisoleHCID 6451240Aluminum(III) ChlorideHCID 219426655-Bromo-2-fluorobenzoyl chloride

生成物 1

HCID 43160485(5-Bromo-2-fluoro-phenyl)-(4-methoxy-phenyl)-methanone収率 64%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 5-bromo-2-fluoro-benzoyl chloride (27.0 g, 114 mmol) and anisole (12.9 g, 13.0 mL, 119 mmol) in dichloromethane (150 mL) at 0° C. was added aluminum trichloride (16.2 g, 119 mmol) portionwise so that the internal temperature remained below 10° C. After stirring for 4 hours at 0° C., the solution was poured over crushed ice and the resulting mixture was stirred. After 30 minutes, the organic phase was removed and the aqueous phase was extracted two times with dichloromethane. The combined organic phases were washed once with aqueous 1M hydrochloric acid solution, once with aqueous 1M sodium hydroxide solution, and once with brine. The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was recrystallized from ethanol to afford (5-bromo-2-fluoro-phenyl)-(4-methoxy-phenyl)-methanone (22.5 g, 64%) as a white solid.

後処理

  1. customremained below 10° C
  2. additionthe solution was poured
  3. customover crushed ice
  4. stirringthe resulting mixture was stirred
  5. waitAfter 30 minutes
  6. customthe organic phase was removed
  7. extractionthe aqueous phase was extracted two times with dichloromethane
  8. washThe combined organic phases were washed once with aqueous 1M hydrochloric acid solution, once with aqueous 1M sodium hydroxide solution
  9. dry with materialThe organic phase was dried over sodium sulfate
  10. filtrationfiltered
  11. concentrationconcentrated under reduced pressure
  12. customThe resulting residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-e74f4d26bc5b4e5689960509010aec5f
出典データセット
uspto-grants-2011_12
特許番号
US08080580B2

反応ノート

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