Formic Acid → N-Pyridin-2-ylmethyl-formamide

HRID 66017ノート

反応式

HRID 66017 の反応式
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[CH:9](O)=[O:10]>>[CH:9]([NH:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)=[O:10]

参加物

3

反応物 2

HCID 284Formic AcidHCID 195092-Pyridinemethanamine

生成物 1

HCID 12228441N-Pyridin-2-ylmethyl-formamide

実験手順

A mixture of 32.4 g. of 2-aminomethylpyridine and 96 ml. of 97% formic acid is heated under reflux for 3.5 hrs. The resulting solution is subjected to vacuum distillation, the desired product being isolated as the fraction boiling at 120° C./0.03 mm, 37.3 g. The product which is isolated as a yellow oil crystallized to a solid having a melting point at about room temperature.

後処理

  1. additionA mixture of 32.4 g
  2. temperatureunder reflux for 3.5 hrs
  3. distillationThe resulting solution is subjected to vacuum distillation

出典と根拠

ORDレコード
ord-4c9dfbe434ad493aa3a7209d2dc84df3
出典データセット
uspto-grants-1978_12
特許番号
US04129567

反応ノート

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