化工社化工社 化学情報印刷レポート · 研究参考用
Nitric Acid → 4-amino-3-nitrophenylPropanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Aminohydratropic acid | HCID 43026 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-amino-3-nitrophenylPropanoic acid | HCID 12226817 | — |
反応手順
A solution of 2-(4-Aminophenyl)propanoic acid (8.45 g, 51.2 mmol) in AcOH (70 mL) was added HNO3 (60%, 5.66 g) at room temperature. The reaction mixture was refluxed for 4 hrs then cooled to room temperature. The mixture was poured into iced water (200 mL), and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08084484B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-19d595998b3a4f71862231140536bfd5 |
| 出典メモ | uspto-grants-2011_12 |