Ethyl 2-(4-amino-3-nitrophenyl)propanoate → Ethyl 2-(3,4-diaminophenyl)propanoate

HRID 660301ノート

反応式

HRID 660301 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][C:3]=1[N+:15]([O-])=O>[C].[Pd].C1COCC1.CCO>[NH2:15][C:3]1[CH:4]=[C:5]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:7][C:2]=1[NH2:1]

参加物

4

反応物 1

HCID 15558027Ethyl 2-(4-amino-3-nitrophenyl)propanoate

生成物 1

HCID 12226827Ethyl 2-(3,4-diaminophenyl)propanoate

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 21873804Tetrahydrofuran ethanol溶媒

実験手順

To the flask was added THF/EtOH (1:1, 50 mL) followed by Ethyl 2-(4-amino-3-nitrophenyl)propanoate (2.12 g, 8.90 mmol) and 10% palladium carbon (220 mg) at room temperature. The reaction mixture was hydrogenated and stirred for 3 hrs at 45 psi then filtered through celite bed, and washed with EtOH. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:4-1:2) as eluant.

後処理

  1. filtrationthen filtered through celite bed
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash column chromatography on silica gel

出典と根拠

ORDレコード
ord-685bce2855ad48f2825085c436acc721
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

反応ノート

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