2-(4-Nitrophenyl)propiononitrile → 2-(4-Aminophenyl)propiononitrile
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:13])[C:11]#[N:12])=[CH:6][CH:5]=1)([O-])=O>[C].[Pd].C1COCC1.CCO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:13])[C:11]#[N:12])=[CH:8][CH:9]=1参加物
4
実験手順
To the flask was added THF/EtOH (1:1, 70 mL) followed by 2-(4-nitrophenyl)-propionitrile (13.2 g, 74.9 mmol) and 10% palladium carbon (1.07 g) at room temperature. The reaction mixture was hydrogenated and stirred for 30 minutes at 47 psi to 28 psi then filtered through celite bed, and washed with EtOAc. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:3) as eluant.
後処理
- filtrationthen filtered through celite bed
- washwashed with EtOAc
- concentrationThe filtrate was concentrated in vacuo
- customThe residue was purified by flash column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-1ae36e6c1d3c41ca91f22fb1d1c97e10
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084484B2
反応ノート
読み込み中…