4-amino-3-nitrophenylPropanoic acid → 2-(3,4-Diaminophenyl)propanoic acid
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[N+:13]([O-])=O>[C].[Pd].CCO.O>[NH2:13][C:3]1[CH:4]=[C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:6]=[CH:7][C:2]=1[NH2:1]参加物
4
実験手順
To the flask was added EtOH/H2O (3.5:1, 45 mL) followed by 2-(4-Amino-3-nitro-phenyl)-propionic acid (5.73 g, 27.3 mmol) and 10% palladium carbon (117 mg) at room temperature. The reaction mixture was hydrogenated and stirred for 5 hrs at 64 psi then filtered through celite bed, and washed with EtOH. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using CH2Cl2:MeOH (10:1) as eluant.
後処理
- filtrationthen filtered through celite bed
- washwashed with EtOH
- concentrationThe filtrate was concentrated in vacuo
- customThe residue was purified by flash column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-357a73832591471fa79c948b01639105
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084484B2
反応ノート
読み込み中…