化工社化工社 化学情報印刷レポート · 研究参考用
4-Amino-5-hydroxy-1,7-naphthalenedisulfonic acid → 5-Hydroxy-4-(5-nitro-o-toluamido)-1,7-naphthalenedisulfonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-5-hydroxy-1,7-naphthalenedisulfonic acid | HCID 67224 | — |
| 反応物 | 2-Methyl-5-nitrobenzoyl chloride | HCID 4436568 | — |
| 反応物 | Sodium Acetate Trihydrate | HCID 23665404 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Hydroxy-4-(5-nitro-o-toluamido)-1,7-naphthalenedisulfonic acid | HCID 56996136 | — |
反応手順
A 16 g portion of 4-amino-5-hydroxy-1,7-naphthalenedisulfonic acid in 120 ml of water is adjusted to pH7.2. A 7.6 g portion of sodium acetate trihydrate and 8.8 g of 2-methyl-5-nitrobenzoyl chloride are added with vigorous stirring. The mixture is stirred overnight at room temperature. The solid is then collected by filtration, washed with water, 80% ethanol, ethanol, ether and dried, giving 13.0 g of 5-hydroxy-4-(5-nitro-o-toluamido)-1,7-naphthalenedisulfonic acid, disodium salt.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04129590 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-b2953d3056304d86be296506b66f4734 |
| 出典メモ | uspto-grants-1978_12 |