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HRID 660545作成日：2026年10月27日
Cesium fluoride → 5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one
https://huagongshe.com/reaction/660545
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium fluoride | HCID 25953 | — |
| 反応物 | 5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one | HCID 68838834 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one | HCID 66757119 | — |
反応手順
To a solution of 5-[2-benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (213 mg, 0.35 mmol) in DMF (3 mL) is added CsF (265 mg, 1.75 mmol). The reaction is stirred at 60° C. for 2 h. The reaction is allowed to cool to RT and the solvent is removed under reduced pressure. The crude cesium salt of the title compound is used in the next step without further purification: (M+H)+=516.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08084448B2 |
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| 出典データセット | uspto-grants-2011_12 |
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| ORD ID | ord-df3f2f0f04754981acdef5cf890756c8 |
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| 出典メモ | uspto-grants-2011_12 |
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