化工社化工社 化学情報印刷レポート · 研究参考用
Azobisisobutyronitrile → Bromo-(2-iodophenyl)-acetic Acid Methyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Methyl 2-(2-iodophenyl)acetate | HCID 640185 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Bromo-(2-iodophenyl)-acetic Acid Methyl Ester | HCID 86632576 | — |
反応手順
A mixture of (2-iodophenyl)-acetic acid methyl ester (14.5 g, 52.5 mmol), NBS (18.7 g, 105 mmol) and AIBN (1.72 g, 10.5 mmol) in CCl4 (300 mL) is refluxed for 10 h. The mixture is cooled to RT and the precipitate filtered. The filtrate is evaporated to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08084448B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-db93df6fcc214a318294e7c39ea96e68 |
| 出典メモ | uspto-grants-2011_12 |