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Dichloromethane → 2,6-Dihydroxybenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 2,6-Dihydroxybenzaldehyde | HCID 10285801 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,6-Dihydroxybenzonitrile | HCID 93791 | — |
反応手順
A mixture of 2,6-dihydroxybenzaldehyde (300 mg, 2.17 mmol) and hydroxylamine sulfate (758 mg, 6.51 mmol) in water (30 mL) is stirred at RT for 45 min. Methylene chloride (60 mL) is added followed by NaHCO3 (911 mg, 10.85 mmol) and the mixture is stirred at RT for 30 min. The organic phase is separated and dried over sodium sulfate and the solvent removed under reduced pressure to give the title compound as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08084448B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-debdfd5d2d5f45438a483499e7fa3ccd |
| 出典メモ | uspto-grants-2011_12 |